Former Lab Members

Title: Research Assistant
Lab member 2012-2016

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Accepted to the University of Massachusetts Medical School, 2016.

Title: Postdoctoral Fellow
Lab member 2015-2017

Publications and awards

Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.

Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1 protein. J Biol Chem. 2012 Aug 17;287(34):28675-85. doi: 10.1074/jbc.M112.378810. Epub 2012 May 29.

Hsu VW, Bai M, Li J. Getting active: protein sorting in endocytic recycling. Nat Rev Mol Cell Biol. 2012 Apr 13;13(5):323-8. doi: 10.1038/nrm3332. Review.

Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May;13(5):559-67. doi: 10.1038/ncb2221. Epub 2011 Apr 17.

Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30;178(3):453-64.

Title: Research Assistant
Lab member 2018-2020

2017 BRI Summer Research Intern from Bates College

Publications and awards

Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.

Brigham Research Institute Research Staff Travel Award 2019

Title: Duke University Medical Student
Lab member 2017-2019

Publications and awards

Rheumatology Research Foundation Medical and Graduate Student Preceptorship entitled “Analyzing transitional care models in chronic illness: CAPRI.”

Title: Research Trainee/Intern
Lab member 2016-2017

Publications and awards

Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.

Title: Harvard Masters in Immunology student
Lab member 2017-2018

Masters student in Nigrovic laboratory to study experimental genetics.

Title: Summer student 2019

Title: Medical student
Lab Member 2021-2022

Mareike is a medical student at Heidelberg University, Germany specializing in clinical immunology. She joined the Grieshaber-Bouyer-Lab in Heidelberg in December 2020 and the Nigrovic Lab in September 2021, continuing the long standing collaboration between the two groups. Working closely together with Dr. Raquel Laza-Briviesca, she studies human neutrophil biology in states of health, acute inflammation, and remission on the example of Kawasaki disease. 

Awards:
Peter-Scriba-Promotionsstipendium der Deutschen Gesellschaft für Innere Medizin [Peter-Scriba-Stipend for doctoral students of the German Society of Internal Medicine] (10.000 €)

Title: Research Assistant
Lab member 2018

Maya contributed to research on resident memory T cells. Maya is from Wisconsin and graduated from Harvard College.

Title: Postdoctoral Fellow
Lab member 2010-2014

Publications and awards

Ercan A, Cui J, Hazen MM, Batliwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N, Weinblatt ME, Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 5; 14(2):R43.

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.

Adamczyk B, Struwe WB, Ercan A, Nigrovic PA, Rudd PM. Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis. J Proteome Res. 2013 Jan 4;12(1):444-54.

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J Clin Invest. 2013 May 1;123(5):2183-92.

Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.

Ercan A, Kohrt W, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, and Nigrovic PA. Estrogens regulate glycosylation of immunoglobulin G in women and men. JCI Insight 2017;2:e89703.

Best Clinical/Translational Abstract Award (BWH Biomedical Research Institute, 2010)

Research Grant, Arthritis National Research Foundation, 2011-2013

Kelly Prize in JIA Research, ANRF, 2011 and 2012 ($150,000)

Research Grant, NIH Building Interdisciplinary Careers in Women’s Health Research (BIRCWH), 2012-2014 ($300,000)

BWH Best Musculoskeletal Research Paper prize 2012

Instructor in Medicine, Harvard Medical School

Assistant Professor of Medicine, Harvard Medical School

2018 Ambassador of the American College of Rheumatology

2019 Visiting Professor of Rheumatology, Guangdong Second Provincial Hospital, Guangzhou China

2019 Socio Correspondiente, Chilean Society for Rheumatology

2019 Harvard Program Award for Culture of Excellence in Mentoring

Title: Research Assistant
Lab member 2010-2012

Publications and awards

Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Accepted to Medical School, 2012.

Title: Summer student 2019

Title: Assistenzarzt, Universitätsklinik Heidelberg, Germany
Lab member since 2016

Publications and awards

Grieshaber-Bouyer R, Kämmerer T, Rosshirt N, Nees TA, Koniezke P, Tripel E, Schiltenwolf M, Kirsch J, Hagmann S, Moradi B. Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis. J Clin Med. 2019 Oct 5;8(10). pii: E1631.

Grieshaber-Bouyer R, Nigrovic PA. Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease. Front. Immunol. 2019 Mar 4;10:346.

Grieshaber-Bouyer R, Nigrovic PA. Maestro endothelium conducts the neutrophils. Blood 2018;132(17):1734-1735.

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017;130(19):2092-2100, doi: https://doi.org/10.1182/blood-2017-03-768507

Grieshaber-Bouyer R and Gerber C. Arthroscopic Repair of Recurrent Posterior Shoulder Subluxation after Total Shoulder Arthroplasty. JBJS Case Connect. 2017;7:e71. doi: https://doi.org/10.2106/JBJS.CC.17.00048

Boehringer Ingelheim Fonds MD Fellowship (2016–2017; €19,200)

German National Academic Foundation (2012–2019)

Title: Postdoctoral Fellow
Lab member 2016-2018

Publications and awards

Halyabar O, Chang MC, Schoettler M, Schwartz MA, Benson L, Biggs CM, Dedeoglu F, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht K, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Degar BA, Hazen MM, Henderson LA. Calm in the Midst of Cytokine Storm: A Collaborative Approach to the Diagnosis and Treatment of Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. Pediatric Rheumatology 2019 Feb 14;17(1):7.

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.

Joint Biology Consortium Microgrant (2017, $5,000)

Title: Assistant Professor of Pediatrics, Harvard Medical School
Lab member/affiliate since 2010

Publications and awards

Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprograming of T cells in systemic juvenile idiopathic arthritis. JCI Insight 2020 Mar 26;5(6). pii: 132508.

Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.

Hou L, Balzaroloc M, Rao DA, Yuki K, Cooley J, Henderson LA, Jonsson AH, Kaisermani D, Gorman MP, Nigrovic PA, Bird PI, Becher B, Remold-O’Donnell E. SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Nat Acad Sci USA 2019 Oct 8;116(41):20635-20643.

Halyabar O, Chang MC, Schoettler M, Schwartz MA, Benson L, Biggs CM, Dedeoglu F, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht K, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Degar BA, Hazen MM, Henderson LA. Calm in the Midst of Cytokine Storm: A Collaborative Approach to the Diagnosis and Treatment of Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. Pediatric Rheumatology 2019 Feb 14;17(1):7.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka C, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivaskiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S and Brenner MB. Pathologically expanded ‘peripheral’ B cell-helper T cells in rheumatoid arthritis. Nature 2017 Feb 1;542(7639):110-114.

Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Son MB, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Lee YN, Nigrovic PA, Notarangelo LD. Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1758-68.

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm Henderson LA, Loring SH, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. J Rheumatol. 2013 Mar; 40(3):273-81.

IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.

Promotion to Instructor in Pediatrics, 2015

Rheumatology Research Foundation Scientist Development Award, 2014-2016 ($125,000)

Rheumatology Research Foundation Investigator Award, 2016-18 ($375,000)

NIAMS K08 AR073339 The Reprogramming of Regulatory T cells to a Th17 Phenotype in Systemic Juvenile Idiopathic Arthritis, 2018-2023 ($525,000)

Boston Children’s Hospital Faculty Career Development Fellowship Award, 2018-2020 ($100,000)

Laboratory Principal Investigator, Boston Children’s Hospital, 2019

Title: Research Specialist
Lab member since 2018

Publications and awards

Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.

Lee PY, Kellner ES, Huang Y, Furutani E, Bainter W, Alosaimi MF, Stafstrom K, Platt CD, Stauber T, Raz S, Tirosh I, Weiss A, Jordan MB, Krupski C, Eleftheriou D, Brogan P, Sobh A, Baz Z, Lefranc G, Kilic SS, El-Owaidy R, Pimpale P, Khubhandani R, Chambers EC, Chou J, Geha RS, Nigrovic PA, Zhou Q. Genotype and functional correlates of disease phenotype in Deficiency of Adenosine Deaminase 2 (DADA2). J Allerg Clin Immunol 2020 Jan 13. pii: S0091-6749(20)30030-0.

Pui Y. Lee, Yuelong Huang, Qing Zhou, Oskar Schnappauf, Michael S. Hershfield, Ying Li, Nancy J. Ganson, Natalia Sampaio Moura, Ottavia M. Delmonte, Scellig S. Stone, Michael Rivkin, Sung-Yun Pai, Todd Lyons, Robert P. Sundel, Victor W. Hsu, Luigi D. Notarangelo, Ivona Aksentijevich, Peter A. Nigrovic. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. The Journal of Allergy and Clinical Immunology. PMID 29936104 DOI: 10.1016/j.jaci.2018.05.038.

Title: Coordinator
Lab member 2016-2019

Former member of Nigrovic laboratory responsible for coordinating the development of NIAMS P30-funded Joint Biology Consortium.

Title: Postdoctoral Fellow
Lab member 2010

Publications and awards

Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Title: Harvard Medical School, Masters of Medical Sciences in Immunology
Lab member since 2019 studying non-coding genetic variants in arthritis

Former member of Nigrovic laboratory responsible for coordinating the development of NIAMS P30-funded Joint Biology Consortium.

Title: Instructor in Pediatrics
Lab member/affiliate since 2012

Publications and awards

Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprograming of T cells in systemic juvenile idiopathic arthritis. JCI Insight 2020 Mar 26;5(6). pii: 132508.

Lee PY*, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA*. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.

Lee PY*, Huang Z, Hershfield MS, Nigrovic PA. Analysis of peripheral blood ADA1 and ADA2 levels in children and adults. Ann Rheum Dis 2020 Feb 13. pii: annrheumdis-2020-217055.

Lee PY*, Kellner ES, Huang Y, Furutani E, Huang Z, Bainter W, Alosaimi MF, Stafstrom K, Platt CD, Stauber T, Raz S, Tirosh I, Weiss A, Jordan MB, Krupski C, Eleftheriou D, Brogan P, Sobh A, Baz Z, Lefranc G, Kilic SS, El-Owaidy R, Pimpale P, Khubhandani R, Chambers EC, Chou J, Geha RS, Nigrovic PA+, Zhou Q+. Genotype and functional correlates of disease phenotype in Deficiency of Adenosine Deaminase 2 (DADA2). J Allerg Clin Immunol 2020 Jan 13. pii: S0091-6749(20)30030-0. (+ co-senior author)

Lee PY*, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA*. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.

Lee PY†*, Nelson-Maney N†, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703. († co-first authors, * co-corresponding authors)

Han S, Zhuang H, Lee PY, Li M, Yang L, Nigrovic PA, Reeves W. Differential responsiveness of monocyte and macrophage subsets to interferon. Arthr Rheum 2020 Jan;72(1):100-113.

Urso K, Caetano-Lopes J, Lee PY, Yan J, Henke K, Sury M, Liu H, Zgoda M, Jacome-Galarza C, Nigrovic PA, Duryea J, Harris MP, Charles JF. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 2019 Jun 5;127:104-113.

Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.

Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman R, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of beta2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Advances 2019 Feb 12;3(3):256-267.

Lee PY, Huang Y, Zhou Q, Schnappauf O, Hershfield MS, Li Y, Ganson NJ, Sampaio Moura N, Delmonte OM, Stone SS, Rivkin M, Pai S-Y, Lyons T, Sundel RP, Hsu VW, Notarangelo LD, Aksentijevich I, Nigrovic PA. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. J Allerg Clin Immunol 2018;142:1363-1365.

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11).

Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology [review]. J Leukoc Biol. 2013 Oct;94(4):585-94.

Lovejoy Resident Research Award, 6/2012 ($6,000)

Lovejoy Resident Research Award, 11/2012 ($5,000)

ACR Resident Research Preceptorship, 2012 ($15,000)

Boston Children’s Medical Staff Organization House Officer Development Award for Empirical Research ($5,000)

Boston Children’s Hospital Alumni Travel Award ($1,000)

Tobé and Stephen E. Malawista Award of the Rheumatology Research Foundation, 2014

Rheumatology Research Foundation Scientist Development Award, 2015-2017 ($125,000)

Marshall J. Schiff, MD Memorial Fellow Research Award, 2015

ACR Distinguished Fellow Award, 2016

Promotion to Instructor in Pediatrics, 2016

Rheumatology Research Foundation Investigator Award, 2017-19 ($375,000)

NIAMS K08 AR074562 Metabolic control of monocyte development and function by amino acids, 2019-2024 ($525,000)

Promotion to Assistant Professor of Pediatrics, Harvard Medical School, 2019

Laboratory Principal Investigator, Boston Children’s Hospital, 2020

Title: Postdoctoral Fellow
Lab member 2015-2019

Publications and awards

Lee PY†*, Nelson-Maney N†, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703. († co-first authors, * co-corresponding authors)

Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.

Joint Biology Consortium Microgrant (2017, $5,000)

Pediatric Rheumatology Symposium Abstract Award, 2017

Marie Skłodowska-Curie Actions Individual Fellowship from the European Commission, 2019

Title: Instructor of Medicine
Lab member 2013-2018

Publications and awards

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.

Promotion to Instructor in Medicine, Harvard Medical School, 2014

Kelly Prize in JIA Research, Arthritis National Research Foundation, 2015 and 2016

Research Grant, Arthritis National Research Foundation, 2015-2017 ($200,000)

Research Grant, National Multiple Sclerosis Society ($50,000)

NIH NINDS R21, 2016 ($275,000)

NIH NIAMS R21 ($275,000)

Title: 2017 and 2018 Summer Research Student from Brandeis University

Title: Postdoctoral Fellow
Lab member since 2016

Publications and awards

Nigrovic PA, Martínez-Bonet M, Thompson SD. Implications of JIA genetic risk variants for disease pathogenesis and classification. [review] Current Opin Rheumatol 2019 Sept;31:401–410

Westra H-J*, Martínez-Bonet M*, Onengut S, Lee A, Luo Y, Das S, Teslovich N, Worthington J, Martin J, Huizinga T, Klareskog L, Rantapaa-Dahlqvist Sm Chen W-M, Quinlan A, Todd J, Eyre S, Nigrovic PA, Gregersen PK, Rich SS, Raychaudhuri S. Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nature Genetics 2018;50:1366-1374. (Martínez-Bonet M, co-first author)

Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.

Martínez-Bonet, M., González-Serna, A., Clemente, M. I., Morón-López, S., Díaz, L., Navarro, M., et al. (2017). Relationship between CCR5(WT/Δ32) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection. Clinical Microbiology and Infection, 23(5), 318-324.

Martínez-Bonet M, Palladino C, Briz V, Rudolph JM, Fackler OT, Relloso M, et al. (2015) A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. PLoS ONE 10(12): e0145239. https://doi.org/10.1371/journal.pone.0145239.

Martínez-Bonet, M., Isabel Clemente, M., Jesús Serramía, M., Muñoz, E., Moreno, S., & Ángeles Muñoz-Fernández, M. (2015). Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1. Scientific Reports, 5, 16445. http://doi.org/10.1038/srep16445.

Martínez-Bonet, M., Puertas, M. C., Fortuny, C., Ouchi, D., Mellado, M. J., Rojo, P., … Martinez-Picado, J. (2015). Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 61(7), 1169–1178. http://doi.org/10.1093/cid/civ456

Sara Borrell Fellowship funded by the Instituto de Salud Carlos III, 2019

Title: Research Assistant
Lab member 2014-2016
2017 summer research student

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Accepted to New York Medical College, 2016

Title: Research Assistant I
Lab member since 2021-2022

Marc completed a Bachelor’s degree in Biology at Davidson College and joined the Nigrovic lab in 2021 as a technician to assist with studies of neutrophils and related biology.

Awards
2022 Joint Biology Consortium Microgrant ($5000)

Title: Postdoctoral Fellow
Lab member 2018-2022 studying non-coding genetic variants in arthritis and lupus

Dr. Qiang Wang is a postdoctoral research fellow working on the identification of new genetic mechanisms in systemic lupus erythematosus and inflammatory arthritis. Dr. Wang received his Bachelor’s degree in Veterinary Medicine from Jilin University, China, followed by his Ph.D. degree at Tufts University.

Publications and awards
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)

Title: Research Assistant II
Lab member 2019-2022

Brian Wauford graduated from Bates College in 2019 and he assists in research on T cells in arthritis and in the biology of IL-1-mediated inflammation.

Awards
2021 Joint Biology Consortium Microgrant ($5000)