Our Team

Dr. Nigrovic is Chief of the Division of Immunology at Boston Children’s Hospital and Professor of Pediatrics at Harvard Medical School. Dr. Nigrovic received a B.A. in philosophy from Amherst College, including a year of study at Corpus Christi College, Oxford, followed by his medical degree at Harvard Medical School. He completed med/peds residency in the Harvard Combined Program and med/peds rheumatology fellowship at Boston Children’s Hospital and the Brigham and Women’s Hospital, where he founded the Nigrovic laboratory in 2010.

Dr. Nigrovic also directs the NIAMS-funded Joint Biology Consortium arthritis research infrastructure. He is Deputy Editor of Arthritis & Rheumatology and serves on the Scientific Advisory Board of the Arthritis National Research Foundation. He was founding co-chair of the pediatric rheumatology mentoring program AMIGO. He received mentoring awards from Harvard Medical School in 2014 and 2019, was elected in 2018 to the American Society for Clinical Investigation (ASCI), and was elected in 2022 to the Association of American Physicians (AAP).

Title: Postdoctoral Fellow
Lab member since 2023

Dr. Bae's research interests are in characterizing the function of neutrophils in arthritis and identifying novel factors in neutrophil-regulating pathology. Dr. Bae received his Bachelor's degree in Biological Sciences and his Ph.D in Immunology from Sungkyunkwan University, South Korea.

Presentations and awards
Bae GH, Kim YS, Park JY, Lee M, Lee SK, Kim JC, Kim JG, Shin YJ, Lee H, Kim SY, Bae YS, Zabel BA, Kim HS, Bae YS. Unique characteristics of lung-resident neutrophils are maintained by PGE2/PKA/Tgm2-mediated signaling. Blood. 2022 Aug 25;140(8):889-899.

Lee SK, Kim YS, Bae GH, Lee HY, Bae YS. VU0155069 inhibits inflammasome activation independent of phospholipase D1 activity. Sci Rep. 2019 Oct 4;9(1):14349.

Lee SK, Bae GH, Kim YS, Kim HS, Lee M, Ghim J, Zabel BA, Ryu SH, Bae YS. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019 May 10;9(1):7242.

Bae GH, Lee SK, Kim HS, Lee M, Lee HY, Bae YS. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8;49(12):e407.

Bae GH, Lee HY, Jung YS, Shim JW, Kim SD, Baek SH, Kwon JY, Park JS, Bae YS. Identification of novel peptides that stimulate human neutrophils. Exp Mol Med. 2012 Feb 29;44(2):130-7.

Title: Research Assistant II
Lab member since 2018

Spoorthi completed a Bachelor’s degree in Biochemistry with a minor in Art History at Barnard College. She joined the lab as a student in 2018 and joined full time in 2021. She is the lead technician and assists with the intravital microscopy core. Spoorthi currently studies neutrophils and related biology. She previously studied interactions of proteins implicated in Alzheimer’s disease in the Austin lab of Barnard College.

Publications and awards
Chang MH*, Levescot A*, Nelson-Maney N, Blaustein RB, Winden KD, Morris A, Wactor A, Balu S, Grieshaber-Bouyer R, Wei K, Henderson LA, Iwakura Y, Clark RA, Rao DA, Fuhlbrigge RC, Nigrovic PA. Arthritis Flares Mediated by Tissue Resident Memory T Cells in the Joint. Cell Rep. 2021 Oct 26;37(4):109902. PMID 34706228.

Joint Biology Consortium microgrant award 2023 ($5,000)

Title: Medical Student
Lab member since 2023

Favian is a fourth-year medical student at Heidelberg University where he began immunological research at the Grieshaber-Buoyer lab. He joined the Nigrovic lab in 2023 as a research fellow to study the mechanism of overt mTOR activation in the pathophysiology of sJIA and Still’s disease in mice. This project will be the center piece of Favian’s MD thesis under the supervision of Dr. Nigrovic and Dr. Pui Lee.

Awards:
2018 Anton Chekov Award
German Academic Scholarship Foundation (13.000 $)

Title: Assistant Professor of Pediatrics
Lab member since 2015

Dr. Chang’s research interests are in site-specific autoimmune diseases, with an emphasis on tissue resident memory T cells and how they contribute to joint-specific memory and arthritis flares, as well as T cell drivers of autoimmune uveitis.

Dr. Chang obtained her M.D./Ph.D. degree from the David Geffen UCLA School of Medicine in 2013. She completed her pediatric residency and pediatric rheumatology fellowship training at Boston Children’s Hospital in 2019.

Publications and awards
Wobma H, Arvila SR, Taylor ML, Lam KP, Ohashi M, Gebhart C, Powers H, Case S, Chandler MT, Chang MH, Cohen E, Day-Lewis M, Fishman MP, Halyabar O, Hausmann JS, Hazen MM, Lee PY, Lo MS, Meidan E, Roberts JE, Son MBF, Sundel RP, Dedeoğlu F, Nigrovic PA, Casey A, Chang J, Henderson LA. Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2023 Apr 11.

Julé AM, Lam KP, Taylor M, Hoyt KJ, Wei K, Gutierrez-Arcelus M, Case SM, Chandler M, Chang MH, Cohen EM, Dedeoglu F, Halyabar O, Hausmann J, Hazen MM, Janssen E, Lo J, Lo MS, Meidan E, Roberts JE, Wobma H, Son MBF, Sundel RP, Lee PY, Sage PT, Chatila TA, Nigrovic PA, Rao DA, Henderson LA. Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. Front Immunol. 2022;13:1068399. 

Huang Z, You X, Chen L, Du Y, Brodeur K, Jee H, Wang Q, Linder G, Darbousset R, Cunin P, Chang MH, Wactor A, Wauford BM, Todd MJC, Wei K, Li Y, Levescot A, Iwakura Y, Pascual V, Baldwin NE, Quartier P, Li T, Gianatasio MT, Hasserjian RP, Henderson LA, Sykes DB, Mellins ED, Canna SW, Charles JF, Nigrovic PA, Lee PY. mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome. Nat Commun. 2022 Nov 28;13(1):6915.

Chang MH, Bocharnikov AV, Case SM, Todd M, Laird-Gion J, Alvarez-Baumgartner M, Nigrovic PA. Joint-Specific Memory and Sustained Risk for New Joint Accumulation in Autoimmune Arthritis. Arthritis Rheumatol. 2022 Nov;74(11):1851-1858. 

Taylor ML, Hoyt KJ, Han J, Benson L, Case S, Chandler MT, Chang MH, Platt C, Cohen EM, Day-Lewis M, Dedeoglu F, Gorman M, Hausmann JS, Janssen E, Lee PY, Lo J, Priebe GP, Lo MS, Meidan E, Nigrovic PA, Roberts JE, Son MBF, Sundel RP, Alfieri M, Yeun JC, Shobiye DM, Degar B, Chang JC, Halyabar O, Hazen MM, Henderson LA. An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J Rheumatol. 2022 Sep;49(9):1042-1051.

Van Der Heijden H, Fatou B, Sibai D, Hoyt K, Taylor M, Cheung K, Lemme J, Cay M, Goodlett B, Lo J, Hazen MM, Halyabar O, Meidan E, Schreiber R, Jaimes C, Ecklund K, Henderson LA, Chang MH, Nigrovic PA, Sundel RP, Steen H, Upadhyay J. Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2022 Jan 15;20(1):3.

Roberts JE, Nigrovic PA, Lo MS*, Chang MH*. Weekly Adalimumab, an Effective Alternative for Refractory Uveitis in Children. J Clin Rheumatol. 2022 Jan 1;28(1):e301-e304. 

Chang MH*, Shantha JG*, Fondriest JJ, Lo MS, Angeles-Han ST. Uveitis in Children and Adolescents. Rheum Dis Clin North Am. 2021 Nov;47(4):619-641.

Chang MH*, Levescot A*, Nelson-Maney N, Blaustein RB, Winden KD, Morris A, Wactor A, Balu S, Grieshaber-Bouyer R, Wei K, Henderson LA, Iwakura Y, Clark RA, Rao DA, Fuhlbrigge RC, Nigrovic PA. Arthritis Flares Mediated by Tissue Resident Memory T Cells in the Joint. Cell Rep. 2021 Oct 26;37(4):109902.

Julé AM, Hoyt KJ, Wei K, Gutierrez-Arcelus M, Taylor ML, Ng J, Lederer JA, Case SM, Chang MH, Cohen EM, Dedeoglu F, Hazen MM, Hausmann JS, Halyabar O, Janssen E, Lo J, Lo MS, Meidan E, Roberts JE, Son MBF, Sundel RP, Lee PY, Chatila T, Nigrovic PA, Henderson LA. Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. JCI Insight. 2021 Sep 22;6(18):e149185.

Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. IL-1β-driven osteoclastogenic T regulatory cells accelerate bone erosion in arthritis. J Clin Invest. 2021 Aug 3:141008. 

Upadhyay J, Lemme J, Cay M, Van Der Heijden H, Sibai D, Goodlett B, Lo J, Hoyt K, Taylor M, Hazen MM, Halyabar O, Meidan E, Schreiber R, Chang MH, Nigrovic PA, Jaimes C, Henderson LA, Ecklund K, Sundel RP. A multidisciplinary assessment of pain in juvenile idiopathic arthritis. Semin Arthritis Rheum. 2021 Jun 4;51(4):700-711.

Halyabar O, Friedman KG, Sundel RP, Baker AL, Chang MH, Gould PW, Newburger JW, Son MBF. Cyclophosphamide use in treatment of refractory Kawasaki disease with coronary artery aneurysms. Pediatr Rheumatol Online J. 2021 Mar 17;19(1):31. 

Lee PY, Day-Lewis M, Henderson LA, Friedman K, Lo J, Roberts JE, Lo MS, Platt CD, Chou J, Hoyt KJ, Baker AL, Banzon T, Chang MH, Cohen E, de Ferranti S, Dionne A, Habiballah S, Halyabar O, Hausmann JS, Hazen M, Janssen E, Meidan E, Nelson RW, Nguyen AA, Sundel RP, Dedeoglu F, Nigrovic PA, Newburger JW, Son MBF. Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 Jul 23

Stoll M, Duck L, Chang MH, Colbert R, Nigrovic P, Thompson S, Elson C. Identification of Prevotella Oralis as a Possible Target Antigen in Children with Enthesitis related arthritis. Clinical Immunology. 2020 May 10; 216:108463

Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Julé AM, Charbonnier LM, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 Mar 26;5(6).

Lee PY, Schulert GS, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Wactor A, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2019 2020 Feb;79(2):225-231.

Chang MH and Nigrovic PA. Antibody-dependent and -independent mechanisms of inflammatory arthritis. JCI Insight. 2019 Mar 7;4(5)

Halyabar O, Chang MH, Schoettler ML, Schwartz MA, Baris EH, Benson LA, Biggs CM, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht KG, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Dedeoglu F, Degar BA, Hazen MM, Henderson LA. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14;17(1):7

Cunin P, Penke LR, Thon HN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, et al. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 2; 127(5):1714-1724

Thiemann S, Man JK, Chang MH, Lee B, Baum LG. Galectin-1 regulates tissue exit of specific dendritic cell populations. J Biol Chem. 2015 Sep 11; 290(37):22662-77.

Fulcher JA*, Chang MH*, Wang S, Almazan T, Hashimi ST, Eriksson AU, Wen X, Pang M, Baum LG, Singh RR, Lee B. Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and PKC signaling. J Biol Chem. 2009 Sep 25; 284(39):256860-70.

Hashimi ST*, Fulcher JA*, Chang MH, Gov L, Wang S, Lee B. MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood. 2009 Jul 9; 114(2):404-14.

Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, and Cole SW. beta-Adrenoreceptors reactivate Kaposi’s sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J Virol. 2005 Nov; 79(21):13538-47.

2023-2025 Boston Children’s Hospital OFD/BTREC/CTREC Faculty Career Development Award
2023-2025 Arthritis National Research Foundation award
2022-2027 K08 Mentored Clinical Scientist Development Award, NIAMS K08AR090992
2021 Joint Biology Consortium microgrant award, NIAMS P30AR070253
2020-2021 K12 Institutional Career Development award, NICHD K12HD052896
2019 Joint Biology Consortium microgrant award, NIAMS P30AR070253
2018 Translation Accelerator Grant, BWH Human Skin Disease Resource Center
2018-2022 Rheumatology Research Foundation Scientist Development Award
2016 American College of Rheumatology Pediatric Research Award
2015 American College of Rheumatology Resident Research Preceptorship
2014 Lovejoy Resident Research Award, Boston Children’s Hospital
2009-2013 F30 Ruth L. Kirschstein National Research Service Award, NHLBI F30HL096392

Title: Assistant Professor of Pediatrics
Director of 2-photon intravital microscopy core
Lab member since 2013

Dr. Cunin obtained his Ph.D. and his Pharm.D. degrees in France in 2012. He is investigating the role of the megakaryocyte/platelet, and neutrophil lineages in systemic inflammation and arthritis. He is also the founding director of a new two-photon intravital imaging core facility of the Division of Immunology (Boston Children’s Hospital), specialized in the imaging of immune organs in live mice (lung, lymph nodes, bone marrow, brain, liver, etc.).

Google Scholar

Publications and awards

Huang FY*, Cunin P*, Radtke FA, Darbousset R, Grieshaber-Boyer R, Nigrovic PA. Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis. Blood Advances 2021; 10, 1082 *contributed equally

Trombetta BA, […], Cunin P, […], Suliman S. Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2. BMC Infections Diseases 2021; 21, 580

Grieshaber-Bouyer R, Radtke F, Cunin P, Stifano G, Levescot A, Vijaykumar B, Nelson-Maney N, Blaustein RB, Monach PA, Nigrovic PA, ImmGen Consortium. The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments. Nature Communications 2021; 12, 2856

Lee PY, Nelson-Maney N, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA. High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI insight 2019; 4 (15)

Cunin P, Nigrovic PA. Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction. Platelets 2019 Nov 21

Cunin P, Nigrovic PA. Megakaryocytes as immune cells. J Leukoc Biol 2019 Jan 15

Cunin P, Bouslama R, Machlus KR, Martinez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife 2019 May 1;8. pii: e44031

Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman RJ, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Adv. 2019 3(3):256-267

Li G, Martinez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nat. Genet. 2018; 50(8):1180-1188

Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZB, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017; blood-2017-03-768507

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Science Immunology 2017; 2(11), eaam6641

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest 2017; 127(5), 1714-1724

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292. 

Cunin P, Beauvillain C, Miot C, Augusto JF, Tan F, Preisser L, Blanchard S, Scotet M, Garo E, Fremaux I, Chevailler A, Subra JF, Blanco P, Wilson M, Jeannin P, Delneste Y. Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced auto-immune responses. Cell Death & Disease. 2016; 7:e2215.

Dellinger AL, Cunin P, Lee D, Kung AL, Brooks DB, Zhou Z, Nigrovic PA, Kepley CL. Inhibition of inflammatory arthritis using fullerene nanomaterials. PLOS One. 2015; 10(4):e0126290.

Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML, Magistrelli G, Masternak K, Chevailler A, Delneste Y, Jeannin P. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood. 2011; 117(4):1196-204.

Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P. The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes. J Immunol. 2011; 186(7):4175-82.

2022 NIH Mentored Research Scientist Development award (K01) 
2022 Gilead Sciences Research Scholars Program in Rheumatology 
2020 Gilead Sciences Research Scholars Program in Rheumatology 
2019 Arthritis National Research Foundation (ANRF) research grant 
2018 Arthritis National Research Foundation (ANRF) research grant 
2018 Joint Biology Consortium microgrant 
2017 Joint Biology Consortium microgrant

Title: Instructor in Pediatrics, Harvard Medical School
Lab member since 2019

Dr. Darbousset completed her Ph.D. in Professor Francoise Dignat-George’s lab (INSERM-UMR 1076) under the supervision of Professor Christophe Dubois at the University of Aix-Marseille in France in December 2013. She was a postdoctoral fellow from 2014 to 2018 in Professor Shaun Jackson’s laboratory, first at the Australian Centre For Blood Diseases (ACBD) and the at the Heart Research Institute (HRI) and the Charles Perkins Centre (CPC), affiliated with Sydney University, Australia.

Research Gate; LinkedIn

Publications and awards
Huang F.Y., Cunin P., Radtke F.A., Darbousset R., Grieshaber-Bouyer R., Nigrovic P.A. Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis. 2022, Blood Advances, Apr 12;6(7):2081-2091.

Crescence, L.; Darbousset R., Caroff, E., et al. Selatorel, a reversible P2Y12 receptor antagonist, has no off-target interference with haemostasis, Thrombosis Research, 200:133-140; 2021.

Makhloufi C., Crescence L., Darbousset R., McKay N., Massy Z.A., Dubois C., Panicot- Dubois L., Burtey S., Poitevin S., Assessment of thrombotic and bleeding tendency in two mouse models of chronic kidney disease: Adenine-Diet and the 5/6th nephrectomy. 2020, TH Open, 16;4(2): e66-e76.

Jackson, SP*.; Darbousset, R*.; Schoenwaelder SM*. Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood. 2019 Feb 28;133(9):906-918. (*) co-first authors.

Mezouar, S.; Frere, C.; Darbousset, R.; et al. Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences. 2016, Thrombosis Research, 139 : 65-76.

Mezouar, S.; Darbousset, R.; Frere, C.; et al. The Biomarkers of Venous Thromboembolism in Cancer Patients. 2016, Oncologie, 18(1): 17-21.

Schoenwaelder S*., Darbousset R*., Crammer S*., Ramshaw H., Orive S., Sturgeon S., Yuan Y., Yao Y., Krycer J. Woodcock J., Pitson S., Zheng Z., Henstridge D., van der Wal D., Gardiner E., Berndt M., Andrews R., James D., Lopez A., Jackson S. 14-3-3ζ regulates the mitochondrial repiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. 2016, Nature Communications, 7:12862 (*) co-first authors.

Darbousset, R.; Delierneux, C.; Mezouar, S.; et al. P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice. 2014, Blood, 124(16): 2575-2585.

Mezouar, S.; Darbousset, R.; Dignat-George, F.; et al. Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo. 2015, International Journal of Cancer, 136(2):462-475.

Mezouar, S.; Mege, D.; Darbousset, R.; et al. Involvement of Platelet-Derived Microparticles in Tumor Progression and Thrombosis. 2014, Seminars in Oncology, 41(3): 346-358.

Darbousset, R.; Mezouar, S.; Dignat-George, F.; et al. Involvement of neutrophils in thrombus formation in living mice. 2014, Pathologie Biologie, 62(1): 1-9.

Hubert, L.; Darbousset, R.; Panicot-Dubois, L.; et al. Neutrophils recruit and activate human endothelial colony-forming cells at the site of vessel injury via P-selectin glycoprotein ligand-1 and L-selectin. 2014, Journal of Thrombosis and Haemostasis, 12(7): 1170-1181

Darbousset, R.; Thomas, GM..; Mezouar, S.; et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. 2012, Blood, 120(10): 2133-2143.

2021 Arthritis National Research Foundation (ANRF), Platelets as neutrophil amplifiers in Systemic sclerosis
2020 Joint Biology Consortium Microgrant, Platelets as neutrophil amplifiers in Systemic sclerosis, NIH P30AR070253

Title: Research Assistant I
Lab member since 2022

Michael completed a Bachelor’s Degree in Human Developmental and Regenerative Biology from Harvard College and joined the Nigrovic Lab in 2022 as a technician to assist with the investigation of tissue-resident lymphocytes and regulatory T cell development. Before the lab, he studied limb regeneration and peripheral nerve regeneration in axolotls in the lab of Assistant Professor Jessica Whited.

Awards
Joint Biology Consortium Microgrant Award 2023 ($5000)
Harvard College Research Program, Summer 2021 ($4200)
Harvard College Research Program, Spring 2020 ($950)
Harvard College Research Program, Fall 2020 ($850)

Title: Research Assistant I
Lab member since 2022

Maryrose completed a Bachelor’s degree in Health Sciences with a minor in Biology at Northeastern University. She joined the Nigrovic lab in 2022 as a technician working under Dr. Margaret Chang, assisting in research of tissue-resident memory T-cells in arthritis flares and mechanisms of uveitis.

Awards
Joint Biology Consortium Microgrant, NIH P30AR070253, 2023 ($5,000)

Title: Research Fellow
Lab member since 2022

Dr. David Hoytema van Konijnenburg completed his MD, PhD at Utrecht University, with PhD research in Immunology completed in the Van Wijk lab in Utrecht and in the Mucida lab at The Rockefeller University in New York, NY. His research focused on intestinal T cells in gut homeostasis, inflammation and infection using a combination of techniques including live imaging. Next, Dr. Hoytema completed pediatrics residency at Boston Childrens Hospital and Harvard Medical School / Boston Medical Center and Boston University (Boston Combined Residency Program in Pediatrics) concurrent with research in the Kirchhausen lab and Zon lab at Harvard Medical School, where he studied the function of tissue-resident immune cells in the skin and tumors. Dr. Hoytema is a current Allergy and Immunology Fellow at Boston Children's Hospital and Harvard Medical School, working in Nigrovic lab and Zanoni lab on tissue-resident immune cells in the lung. 

Publications and awards
Silva HM, Báfica A, Rodrigues-Luiz GF, Chi J, Santos PDA, Reis BS, Hoytema van Konijnenburg DP, Crane A, Arifa RDN, Martin P, Mendes DAGB, Mansur DS, Torres VJ, Cadwell K, Cohen P, Mucida D, Lafaille JJ. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 2019 04 01; 216(4):786-806. PMID: 30862706.

Lutter L, Hoytema van Konijnenburg DP, Brand EC, Oldenburg B, van Wijk F. The elusive case of human intraepithelial T cells in gut homeostasis and inflammation. Nat Rev Gastroenterol Hepatol. 2018 10; 15(10):637-649. PMID: 29973676.

Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018 10 01; 128(10):4669-4681. PMID: 30198907; PMCID: PMC6159979.

Hoytema van Konijnenburg DP*, Reis BS*, Pedicord VA, Farache J, Victora GD, Mucida D. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017 Nov 02; 171(4):783-794.e13. PMID: 28942917.\

Hoytema van Konijnenburg DP, Mucida D. Intraepithelial lymphocytes. Curr Biol. 2017 Aug 07; 27(15):R737-R739. PMID: 28787597.

Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016 Jun 24; 352(6293):1581-6.PMID: 27256884.

Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014 Aug 21; 41(2):244-56. PMID: 25148025.

van de Ven AA, Hoytema van Konijnenburg DP, Wensing AM, van Montfrans JM. The role of prolonged viral gastrointestinal infections in the development of immunodeficiency-related enteropathy. Clin Rev Allergy Immunol. 2012 Feb; 42(1):79-91. PMID: 22116710.

van de Ven AA, de Jong PA, Hoytema van Konijnenburg DP, Kessels OA, Boes M, Sanders EA, Terheggen-Lagro SW, van Montfrans JM. Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency. Clin Exp Immunol. 2011 Aug; 165(2):235-42. PMID: 21635229.

van de Ven AA, van Montfrans JM, Terheggen-Lagro SW, Beek FJ, Hoytema van Konijnenburg DP, Kessels OA, de Jong PA. A CT scan score for the assessment of lung disease in children with common variable immunodeficiency disorders. Chest. 2010 Aug; 138(2):371-9. PMID: 20299624.

2022 Bravo! Way to Shine Star Award, Boston Children's Hospital
2022 Fellow Teaching Honor Roll, Boston Combined Residency Program in Pediatrics (BCRP)
2021 Chrysalis Project participant, American Academy of Allergy, Asthma & Immunology (AAAAI)
2020 House Staff Development Award, Medical Staff Organization, Boston Children's Hospital
2020 Fred Lovejoy Resident Research Award, Boston Children's Hospital
2020 Trainee Travel Award for Excellence, Alumni Association, Boston Children's Hospital
2018 PhD Thesis Award, Pediatrics Association of the Netherlands (NVK), Section on Infection & Immunity
2015 Academy Ter Meulen Award, Royal Netherlands Academy of Arts & Sciences
2015 Co Rosberger Award, Prins Bernhard Cultuurfonds
2015 Travel Grant, Federation of Clinical Immunology Societies (FOCIS)
2015 Talma Eykman Thesis Award in Medicine, Biomedical Sciences or Health Sciences, Utrecht University
2015 National Prize for medical student, The Professor Chris Gips Foundation for Young Scientific Talent 
2014 Pilot Project Award, Helmsley Charitable Trust / The Rockefeller University
2013 Student Research Award, Dutch Digestive Foundation
2008-2014 Alexandre Suerman MD/PhD Honors Program in Medicine, Utrecht University

Title: Postdoctoral Fellow
Lab member since 2018 studying non-coding genetic variants in arthritis

Dr. Taehyeung Kim is a postdoctoral research fellow working on the identification of novel mechanisms in autoimmunity mediated by non-coding genetic variants. Dr. Kim received his Bachelor’s degree in Biochemistry from Chungnam National University, South Korea, followed by his Ph.D. degree at Korea Advanced Institute of Science and Technology.

Awards
2020 Joint Biology Consortium Microgrant, NIH P30AR070253 ($5,000)
2019 Joint Biology Consortium Microgrant, NIH P30AR070253 ($5,000)

Title: Postdoctoral Fellow
Lab member since 2022

Julia Kuehn is a postdoctoral research fellow working on megakaryocyte and platelet biology with a focus on emperipolesis and inflammation. She graduated from medical school and received her M. Sc. degree in Experimental Medicine from the University of Muenster, Germany in August 2022.

Publications and awards
Kuehn J, Schleifenbaum S, Hendling M, Siebenhandl S, Krainer J, Fuehner S, Hellige A, Park C, Hinze C, Wittkowski H, Holzinger D, Thurner L, Weinhäusel A, Foell D, Kessel C. Aberrant Naive CD4-Positive T Cell Differentiation in Systemic Juvenile Idiopathic Arthritis Committed to B Cell Help. Arthritis Rheumatol. 2023 May;75(5):826-841. 

Kuehn J, Espinoza-Sanchez NA, Teixeira FCOB, Pavão MSG, Kiesel L, Győrffy B, Greve B, Götte M. Prognostic significance of hedgehog signaling network-related gene expression in breast cancer patients. J Cell Biochem. 2021 May;122(5):577-597.

2022 Research Award by the German Society of Pediatric Rheumatology
Academic Scholarship, awarded by the German Academic Scholarship Foundation ($15,000)

Title: Postdoctoral Research Fellow
Lab member since 2021

Dr. Laza-Briviesca completed her bachelor’s degree in biology and a PhD in Molecular Biosciences at the Autonoma University of Madrid, Spain. Dr. Laza-Briviesca has been working in the immunology field since 2013 focusing on NK cells as a Research Assistant at the Anthony Nolan Research Institute (London, UK). Her PhD was focused on immunophenotyping lung cancer patients (Madrid, Spain). As a postdoctoral research fellow, she is studying regulatory T cells in chronic inflammation and arthritis.

OrCID; Research Gate; LinkedIn

Publications and awards
Rocha P et al. Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC. Clin Cancer Res 2022 Jun 1;28(11):2461-2473.

Sierra-Rodero B et al. Clinical and Molecular Parameters Associated to Pneumonitis Development in Non-small Cell Lung Cancer Patients Receiving Chemoimmunotherapy from NADIM trial. J Immunother Cancer. 2021 Aug;9(8):e002804.

Casarrubios M et al., Pre-treatment Tissue TCR repertoire evenness is associated to complete pathological response in NSCLC patients receiving neoadjuvant chemoimmunotherapy from NADIM trial. Pre-treatment. Clin Cancer Res. 2021 Nov 1;27(21):5878-5890.

Laza-Briviesca R et al. Blood Biomarkers Associated to Complete Pathological Response on NSCLC Patients Treated with Neoadjuvant Chemoimmunotherapy Included in NADIM Clinical Trial. Clin Transl Med. 2021 Jul;11(7):e491.

Provencio M et al. Neoadjuvant Chemotherapy plus Nivolumab in Resectable Stage IIIA Non Small-Cell Lung Cancer: an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020 Nov;21(11):1413-1422.

Cox ST et al. Functional characterisation and analysis of the soluble NKG2D ligand repertoire detected in umbilical cord blood plasma. Front Immunol. 2018 Jun 15;9:1282.

Laza-Briviesca R et al. Treatment of umbilical cord blood units with interleukin-15 improves hematopoietic stem cell engraftment. Cir Cir. 2016 Jul-Aug;84(4):267-8.

Laza-Briviesca R et al. Further polymorphism in the 5’ promoter region of the MHC class I-related chain B gene. Int J Immunogenet. 2016 Feb;43(1):45-8.

Escobedo-Cousin M et al. Natural killer cells improve hematopoietic stem cell engraftment by increasing stem cell clonogenicity in vitro and in a humanized mouse model. PLoS One. 2015 Oct 14;10(10):e0138623.

Cox ST et al. Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol. 2015 Aug;45(8):2324-34

Laza-Briviesca R, Saudemont A, Madrigal JA, Cox ST. Two novel 5’ promoter sequences of the MHC class I-related chain A gene. Int J Immunogenet. 2015 Jun;42(3):226-7. 

Joint Biology Consortium Microgrant Award 2023 ($5000)
Award of Young researchers in lung cancer from GECP (25000)

Title: Postdoctoral Fellow
Lab member since 2021

Dr. Sangwan Sim is a postdoctoral research fellow working on the identification of novel mechanisms mediated by non-coding genetic variants and neutrophils in arthritis. Dr. Sim received his Bachelor’s degree and Ph.D. degree in Immunology and Biochemistry from Korea University, South Korea.

Publications and awards
Sim SW, Park TS, Kim SJ, Park BC, Weinstein DA, Lee YM, Jun HS. Aberrant proliferation and differentiation of glycogen storage disease type Ib mesenchymal stem cells. FEBS Lett. 2018 592(2):162-171.

Hwang EM, Sim SW, Park SH, Son KD, Lee HK, Heo TH, Jun HS, Kim SJ. Anti-proliferative effect of Zea mays L. cob extract on rat C6 glioma cells through regulation of glycolysis, mitochondrial ROS, and apoptosis. Biomed Pharmacother. 2018 98:726-732.

Sim SW, Weinstein DA, Lee YM, Jun HS. Glycogen storage disease type Ib: role of glucose-6-phosphate transporter in cell metabolism and function. FEBS Lett. 2020 594(1):3-18.

Sim SW, Jang YY, Park TS, Park BC, Lee YM, Jun HS. Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type Ib. Cell Mol Life Sci. 2022 79(5):246.