Publications and Awards
Publications
Notable papers
Grieshaber-Bouyer R, Exner T, Hackert NS, Radtke FA, Jelinsky SA, Halyabar O, Wactor A, Karimizadeh E, Brennan J, Schettini J, Jonsson H, Rao DA, Henderson LA, Müller-Tidow C, Lorenz HM, Wabnitz G, Lederer JA, Hadjipanayis A, Nigrovic PA. Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint. Ann Rheum Dis. 2022 Feb 15:annrheumdis-2021-221866. doi: 10.1136/annrheumdis-2021-221866. Epub ahead of print. PMID: 35168946.
Grieshaber-Bouyer R, Radtke FA, Cunin P, Stifano G, Levescot A, Vijaykumar B, Nelson-Maney N, Blaustein RB, Monach PA, Nigrovic PA. The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments. Nature Comm 2021 May 17;12(1):2856. doi: 10.1038/s41467-021- 22973-9. PMID: 34001893; PMCID: PMC8129206.
Nigrovic PA, Colbert RA, Holers VM, Ozen S, Ruperto N, Thompson SD, Wedderburn LR, Yeung RSM, Martini A. Biological classification of childhood arthritis: roadmap to a molecular nomenclature. Nat Rev Rheumatol. 2021 May;17(5):306.
Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020;79(2):225-31. doi: 10.1136/annrheumdis-2019- 216030. Epub 2019 Nov 9. PMID: 31707357; PMCID: PMC7385992.
Nigrovic PA, Lee PY, Hoffman HM. The monogenic autoinflammatory diseases: conceptual overview, phenotype, and clinical approach. J Allerg Clin Immunol. 2020 Nov;146:925-37.
Henderson LA, Canna SW, Schulert GS, Volpi S, Lee PY, Kernan KF, Caricchio R, Mahmud S, Hazen MM, Halyabar O, Hoyt KJ, Han J, Grom AA, Gattorno M, Ravelli A, de Benedetti F, Behrens EM, Cron RQ, Nigrovic PA. On the alert for cytokine storm: Immunopathology in COVID-19. Arthritis Rheum 2020 Jul;72(7):1059-1063. doi: 10.1002/art.41285. Epub 2020 May 10. PMID: 32293098; PMCID: PMC7262347.
Cheng HD, Tirosh I, de Haan N, Stöckmann H, Adamczyk B, McManus CA, O’Flaherty R, Greville G, Saldova F, Bonilla F, Notarangelo LD, Driessen GJ, Holm IA, Rudd PM, Wuhrer M, Ackerman ME* and Nigrovic PA. IgG Fc glycosylation as an axis of humoral immunity in childhood. J Allerg Clin Immunol. 2020;145(2):710- 13. doi: 10.1016/j.jaci.2019.10.012. Epub 2019 Oct 24. PMID: 31669096; PMCID: PMC7010538.
Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Case S, ; Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprograming of regulatory and effector T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 Mar 26;5(6). pii: 132508. doi: 10.1172/jci.insight.132508. PMID: 32213704; PMCID: PMC7213804.
Cunin P, Nigrovic PA. Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction. Platelets. 2019 Nov 21:1-7.
Nigrovic PA, Martínez-Bonet M, Thompson SD. Implications of juvenile idiopathic arthritis genetic risk variants for disease pathogenesis and classification. Current Opin Rheumatol. 2019;31:401-10. doi: 10.1097/BOR.0000000000000637. PMID: 31169548; PMCID: PMC6800096.
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife. 2019;8:e44031. doi: 10.7554/eLife.44031. PMID: 31042146; PMCID: PMC6494422.
Grieshaber-Bouyer R, Nigrovic PA. Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease. Front Immunol. 2019;10:346. doi: 10.3389/fimmu.2019.00346. PMID: 30886615; PMCID: PMC6409342.
Cunin P, Nigrovic PA. Megakaryocytes as immune cells. J Leukoc Biol. 2019;105(6):1111-21. doi: 10.1002/JLB.MR0718-261RR. Epub 2019 Jan 15. PMID: 30645026; PMCID: PMC6984013.
Chang MH, Nigrovic PA. Antibody-dependent and -independent mechanisms of inflammatory arthritis. JCI Insight. 2019;4(5). pii: 125278. doi: 10.1172/jci.insight.125278. PMID: 30843881; PMCID: PMC6483516.
Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman R, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Adv. 2019;3(3):256-67. doi: 10.1182/bloodadvances.2018026732. PMID: 30696624; PMCID: PMC6373735.
Westra H-J, Martínez-Bonet M, Onengut S, Lee A, Luo Y, Das S, Teslovich N, Worthington J, Martin J, Huizinga T, Klareskog L, Rantapaa-Dahlqvist Sm Chen W-M, Quinlan A, Todd J, Eyre S, Nigrovic PA, Gregersen PK, Rich SS, Raychaudhuri S. Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nat Genet. 2018;50(10):1366-74. doi: 10.1038/s41588- 018-0216-7. Epub 2018 Sep 17. PMID: 30224649; PMCID: PMC6364548.
Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction. Nat Genet. 2018;50(8):1180-88. doi: 10.1038/s41588-018-0159-z. Epub 2018 Jul 16. PMID: 30013183; PMCID: PMC6072570.
Cheng HD, Stöckmann H, Adamczyk B, McManus CA, Ercan A, Holm IA, Rudd PM, Ackerman ME*, Nigrovic PA. High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis. Glycobiology. 2017;27(12):1099-108. doi: 10.1093/glycob/cwx082. PMID: 28973482; PMCID: PMC5881781.
Bai M, Grieshaber-Bouyer R, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017;130(19):2092-100. doi: 10.1182/blood-2017-03-768507. Epub 2017 Aug 14. PMID: 28807980; PMCID: PMC5680608.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017;2(11):eaam6641. doi: 10.1126/sciimmunol.aam6641. PMID: 28763796; PMCID: PMC6953719.
Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest. 2017;127(5):1714-24. doi: 10.1172/JCI84598. Epub 2017 Apr 4. PMID: 28375155; PMCID: PMC5409069.
Ercan A, Kohrt W, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, and Nigrovic PA. Estrogens regulate glycosylation of IgG in women and men. JCI Insight. 2017;2:e89703. doi: 10.1172/jci.insight.89703. PMID: 28239652; PMCID: PMC5313059.
Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLoS Genet. 2016;12:e1006292. doi: 10.1371/journal.pgen.1006292. PMID: 27626929; PMCID: PMC5023119.
Wang JX, Kaieda S, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Natl Acad Sci U S A. 2014;111(28):10281-6. doi: 10.1073/pnas.1404182111. Epub 2014 Jun 30. PMID: 24982172; PMCID: PMC4104908.
Wang J, Bair A, King S, Shnayder R, Hsieh YF, Shieh C-C, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a β-2 integrin-dependent mechanism. Blood. 2012;120(7):1489- 98. doi: 10.1182/blood-2012-01-404046. Epub 2012 Jun 1. PMID: 22661700; PMCID: PMC3423786.
Nigrovic PA, Mannion M, Prince FH, Zeft A, Rabinovich CE, van Rossum, MA, Cortis E, Pardeo M, Miettunen PM, Janow G, Birmingham J, Eggebeen E, Janssen E, Shulman AI, Son MB, Hong S, Jones K, Ilowite NT, Cron RQ, Higgins GC. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum. 2011;63(2):545-55. doi: 10.1002/art.30128. PMID: 21280009.
Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt, Massarotti EM, Remold-O’Donnell E, Farndale RW, Ware J, Lee DM. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 2010;327(5965):580-3. doi: 10.1126/science.1181928. PMID: 20110505; PMCID: PMC2927861.
Nigrovic PA, Binstadt BA, Monach PA, Johnsen A, Gurish M, Iwakura Y, Benoist C, Mathis D, Lee DM. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A. 2007;104(7):2325-30. doi: 10.1073/pnas.0610852103. Epub 2007 Feb 2. PMID: 17277081; PMCID: PMC1892913.
Awards
2022 Elected to Association of American Physicians (AAP)
2021 Prince Turki bin Abdul Aziz al-Saud Chair in Pediatrics., Harvard Medical School
2021 Professor of Pediatrics., Harvard Medical School
2021 Keynote address, Pediatric Rheumatology Symposium (PRSYM)
2021 Chief, Division of Immunology, Boston Children’s Hospital
2018 Elected to American Society for Clinical Investigation (ASCI)
2018 Southwest Clinic and Research Institute Endowed Lectureship, Tucson AZ
2017 Kennedy Lectureship, University of Alabama at Birmingham
2017 Pediatric Rheumatology Symposium Abstract Award
2016 Kelly Prize in Juvenile Arthritis Research, Arthritis National Research Foundation
2015 Marshall J. Schiff, MD Memorial Fellow Research Award
2015 Kelly Prize in Juvenile Arthritis Research, Arthritis National Research Foundation
2014 Tobé and Stephen E. Malawista Award of the Rheumatology Research Foundation
2014 HMS Young Mentor Award
2012 Brigham Research Institute Musculoskeletal Best Paper Award
2012 Kelly Prize in Juvenile Arthritis Research, Arthritis National Research Foundation
2011 Arthritis & Rheumatology top 10 cited paper
2011 Kelly Prize in Juvenile Arthritis Research, Arthritis National Research Foundation
2011 Jack and Vonnie Schlomer Award, Arthritis National Research Foundation
2009 John Vaughan Award, Arthritis National Research Foundation